Wow! Our cats are actually doing REALLY well in the car on our trip east. They have been in the car about 6 hours all together. One we barely hear a peep from, the other who is super loud anytime she is in the car is so much quieter and even sleeping!
I'm guessing the anti anxiety medicine the vet prescribed is really working! It's a transdermal med (specifically called Amitriptyline) that I rub on the skin in their ear each day. They are on day five or six now. I think I paid $12 for each of them. So worth it!!
The vet also gave me Feliway wipe samples. I wipe those on their kennel each morning. So that could be making a difference too.
We left their kennels out for the last several weeks with the doors off and installed a piece of carpet in the bottom. They have spent time in them off and on. And over the two previous days they hung out in them in our bathroom while movers were packing and loading. I think they have come to see them as a safe place. 
So it's all good and peaceful on our trip and I couldn't ask for a better experience for them as far as the car ride goes.
As for the hotel, one cat just has to hide. Currently she is under a recliner chair in our hotel room. The other cat is sitting on the window ledge looking down from our eight floor hotel room. I feel bad the one seems so afraid, but she did eat some tuna I offered earlier so she is likely fine and will settle in once we are at our corporate apartment in a couple days.
I'm pretty sure I will be sending an email to our vet to let him know that his advice and care for our cats during our trip was spot on!
Report: Cats Traveling Well
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Happy and safe travels, CCF!
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We stopped after about 8 hours at a hotel and both cats did really well. My non-vocal chill cat was totally fine and my vocal-old lady was good after about 20 minutes of hiding. Then she ate and was normal again
Glad to hear your trip is also doing well!